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[39] The resulting compound 17 , a tetrahydropyridine analogue bearing an acetyl group, manifested 24.5-fold increased enzymatic inhibition activity and more potent cellular potency relative to the hit 16 (IC 50 = 0.71 nM for BTK and 5 nM for OCI-Ly10 cells)

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“Neuron‐Astrocyte Metabolic Coupling Protects Against Activity‐Induced Fatty Acid Toxicity.” Cell 177: 1522–1535.e1514