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[3] Potency: IC₅₀: ~1.0–1.2 µM for NNMT inhibition [1] EC₅₀: 2.3 ± 1.1 µM (reduction of intracellular 1-MNA levels) [1] Lipogenesis Inhibition: 30 µM reduced lipogenesis by 50%

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In addition, regional differences in tyrosine hydroxylase expression exist in areas such as the VTA, which is particularly sensitive to cocaine-induced changes in tyrosine hydroxylase [22, 41]