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Additionally, and in contrast to paclitaxel treatment, oxaliplatin did not increase macrophage infiltration or accumulation in the sciatic nerve, and treatment with a macrophage depletor did not prevent or reverse allodynia in mice, but pretreatment with thrombomodulin (an endothelial transmembrane protein that sequestrates and degrades HMGB1) did prevent oxaliplatin-induced sensory neuropathy (Tsubota et al., 2019)

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