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Given that NNMT has been reported to be a primary metabolic enzyme[36] and a major clearance pathway for intracellular NA,[15] it is likely that these small molecules are directly and selectively inhibiting the conversion of NA to 1-MNA

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Most available findings originate from cell-culture systems, mechanistic laboratory studies, and other non-clinical research models designed to examine how peptide-bound copper interacts with biological signaling networks