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AF-2) in the ligand binding domain of the receptor, enabling it to interact with coregulators that contain specific LXXLL motif(s) 17,18,19,20 and (b) subtle differences in the structure of bound ligands can alter the shape of the AF-2 pocket allowing differential engagement of coregulators 21,22

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How Does the NIH Initiative to Prioritize Human-Based Research Affect Research Proposing the Use of Laboratory Animals

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