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Aqueous solutions are inherently less stable than dry lyophilized material because: - Water enables hydrolysis of peptide bonds - Dissolved oxygen can cause oxidation of sensitive residues - Microbial contamination becomes possible without a preservative - The disulfide bridge is more vulnerable to reduction by trace contaminants Immediate Aliquoting Is Essential The best practice after reconstituting cagrilintide is to immediately divide the stock solution into single-use aliquots before any freeze-thaw cycles occur

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