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Recently, the antipruritic effect of curcumin was found to be mediated through the Mas-related G-protein-coupled receptor B2 (MRGPRB2), the rodent homolog of the human MRGPRX2, as demonstrated by inhibition of C48/80-induced calcium influx in mouse peritoneal MC in a concentration-dependent manner

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Curr Opin Immunol (2009) 21(3):346–51.10.1016/j.coi.2009.05.016 326 Centers for Disease Control Prevention