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Furthermore, the reprogramming process involves genetic and epigenetic modifications, which may have unpredictable consequences, emphasizing the need for ongoing ethical oversight [231]

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High-fat-induced obese rats received daily oral gavage with Met and/or L-car, followed by serum biochemical analysis, histopathological observation on adipose tissues, and immunochemistry test for the abdominal expression of BAT-specific uncoupling protein 1 (UCP1)