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When MTHFR enzyme function is deficient, B12 remains inactive

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For nutrients that are suitable for sublingual delivery, this pathway can: Begin absorption rapidly Bypass hepatic first-pass metabolism before initial systemic entry Reduce dependence on digestive processes for initial uptake Offer a convenient alternative for people who dislike swallowing tablets Researchers have also highlighted that ease of administration and patient acceptability are important contributors to compliance—particularly in children, older adults and people who have difficulty swallowing conventional dosage forms