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Oxidation of cysteine residues can result in a wide range of redox-based, post-translational modifications, including S-nitrosylation, S-glutathionylation and sulfinic acid, sulfenic acid and disulfide formation 22,23 , which can generate conformational changes in protein structure and subsequent modulation of protein activity 24

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Light induces an inflammatory stress on the iRPE Previous studies on rat highlighted that exposure to white light from LED devices induced the activation of the Nuclear Factor-kappa B (NFκB) pathway via the Protein Kinase C zeta (PKCζ) in the retina 9,13