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15,16,17,18 These ROS—such as superoxide anion (O₂•⁻), hydrogen peroxide (H₂O₂), hydroxyl radical (•OH), and peroxynitrite (ONOO⁻)—induce lipid peroxidation, protein oxidation, and DNA damage, thereby activating cell death pathways including apoptosis, necrosis, necroptosis, and autophagy