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Although not generally recommended, Phase III trials can be initiated with an SC vial presentation with an introduction of the SC injection device later, such as in an open-label extension

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In line with this observation, the pre-administration of DSePA (2 mg/Kg bodyweight) for five consecutive days significantly improved the 30-day survival of mice against the lethal dose (γ-rays, 10 Gy) of WBI by preventing lipid peroxidation, DNA damage, and apoptosis in the radiosensitive organs like the spleen and small intestine [88, 89]