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There is also a rapidly growing panel of potential biomarkers of SLE risk or early disease including anti-dense fine speckled 70 (DFS70) as a rule-out SARD test (173), anti-C1q antibodies as a rule-in test (174), cytokines and chemokines (175, 176), IFN signature (177), as well as markers of complement activation (178)

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HER2 is another receptor TK in the ErbB/HER family, which together with EGFR encodes a membrane-bound glycoprotein TK that binds to other ligands to form a heterodimer and activates downstream signaling [23]