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Transition metal–based carriers (e.g., MnO₂, Cu 2 ⁺, Fe 3 ⁺) provide an additional layer of functionality, as they can both deplete intracellular GSH and generate reactive oxygen species, thereby amplifying oxidative stress within tumors

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Surprisingly, increased p21 level was observed in the FOXO4-DRI pre-treatment groups, suggesting senolytics might be a potential stressor to cells