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The amino acid sequences of the HLA-DR molecule determine the shape and affinity to the antigen presenting cleft (119)

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Lastly, to address the affordability and route of administration of biologics, low molecular weight antagonists of IL-6 signaling that target IL-6/IL-6R/gp130 complex are being engineered using structure-guided medicinal chemistry, emphasizing structure-based design, molecular docking, and protein-protein interaction (PPI) principles, with definitive experimental frameworks for optimization (38, 251, 256)