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[DOI] [PubMed] [Google Scholar] 71.Esterbauer H, Schaur RJ, Zollner H

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In RA, ROS are thought to directly contribute to destructive and proliferative synovitis and, thus, play an essential role in pathophysiology of RA.[3,4] Moreover, high levels of ROS can contribute to osteoclast differentiation via RANKL signaling, inducing bone and cartilage destruction