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Similarly, calcitriol (1,25-dihydroxyvitamin D 3 ), the hormonally active metabolite of vitamin D, can also activate sirtuin 1 [114] and downregulate pro-inflammatory and growth signaling pathways, demonstrating anticancer activity in animal models of prostate and breast cancer [115]

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Anderson EJ, Rodriguez E, Anderson CA, Thayne K, Chitwood WR, Kypson AP