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High-risk patients include: Those who received colchicine prophylaxis within the last 14 days and have normal renal and hepatic function, but are taking potent P-glycoprotein or CYP3A4 inhibitors Those who used colchicine prophylaxis within the last 14 days and are on moderate CYP3A4 inhibitors Patients with advanced hepatic or renal impairment (eg, Child-Pugh C cirrhosis or CrCl 9 mg/dL The decision to start ULT should be individualized and shared with the patient

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Other examples of possible treatments include: Changing what you eat, especially switching to a low-salt (sodium) diet Adjusting how active you are Quitting tobacco use or drinking less alcohol Taking medications that reduce inflammation Taking medications like prescription diuretics (“water pills”) that help your body get rid of excess fluid Receiving hanging medications (if they’re causing or contributing to your edema) Using cold packs or ice for swelling from minor injuries Getting treatment for sleep apnea Because treatments can vary, you should talk to your healthcare provider about treatment options