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The FN III subunit features a binding domain known as FN III 12-14 , which contains positively charged amino acids, lysine, and arginine, facilitating interactions with multiple bioactive proteins, including TGF-β, BMP-2, BMP-6, BMP-7, PDGF-BB, and HGF

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Researchers discovered that this small portion of HGH retained the lipolytic (fat-burning) activity of the full hormone while eliminating its growth-promoting and insulin-like effects