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SIRT1 directly interacts with FXR, deacetylating it and increasing the expression of LXRs and their downstream target genes, thereby promoting reverse cholesterol transport in the liver and alleviating hepatic steatosis [28]

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2462-C RESMETIROM IMPROVES THE ATHEROGENIC LIPID/LIPOPROTEIN PROFILE IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS: 52-WEEK DATA FROM THE PHASE 3 MAESTRO-NASH TRIAL Naim Alkhouri 1 , Pierre Bedossa 2 , Cynthia D