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Random on-off patterns without clinical rationale may reduce effectiveness

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They utilized dark pretreatment and found that the expression of both MpGSTZ1 and MpGSTU2 remained unchanged following transfer to the darkness, whereas the expression of MpGSTU1 and MpGSTF1 decreased by ~50 and 75%, respectively, when plants were placed in the dark for 2 h (Dean et al., 2002) found that herbicide safener mefenpyr-diethyl treatment significantly increased GST activity and the expression of HvGST6 (phi class) in dark-grown barley ( Hordeum vulgare L