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From a clinical point of view, T2DM patients are often accompanied by obesity, atherosclerotic disease, dyslipidemia, and hypertension (3, 4), in which more than 50% of T2DM patients have been reported to be obese (3, 5)

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23 Due to the superior efficacy of antioxidative enzymes in scavenging ROS compared to exogenous molecules, the antioxidative effects mediated by NRF2 are notably significant