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3.3 The microenvironment of IVD The unique anatomical position and function of the IVD confer intrinsic physicochemical properties that create a challenging microenvironment for both resident and exogenously transplanted cells, potentially compromising their viability and functionality (Liang et al., 2012)

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In inflammation, immune cells (e.g., neutrophils and macrophages) arrive at the wound’s site and help eliminate pathogens and cell debris