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Glutathione levels are also found to be decreased in central nervous system disorders (such as Alzheimer disease and Parkinson disease), autism, cardiovascular system disorders (atherosclerosis), peripheral vascular disorders, diabetes and its complications, liver disease, acquired immunodeficiency syndrome/human immunodeficiency virus, and chronic obstructive pulmonary diseases

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The authors concluded that insulin resistance (regardless of the presence of diabetes) is significantly associated with HCC development in patients with chronic HCV infection (143)