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In MCF-7 cells, TGF-β-induced GLS1 expression is mediated by the transcription factor Dlx-2, leading to enhanced glutamine metabolism that contributes to EMT ( GLS1 expression via Smad3 and p38 and promotes myofibroblast differentiation ( Tryptophan metabolism, especially in immune cells, exemplifies another aspect of amino acid metabolism modulated by TGF-β signaling (Table 1C)

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According to PubMed: A systematic review of elevated B12, cancer and mortality (2024) What was found: a team at Pontificia Universidad Javeriana in Bogota pooled thirteen studies of adults with abnormally high B12