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In particular, given the limitations and biases of current studies as delineated throughout the manuscript, studies able to demonstrate a causal impact of vitamin D supplementation on fatigue mitigation (such as randomized controlled clinical trials) should be conducted in order to translate the evidence about vitamin D ability to control fatigue in clinical practice

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Bioinformatic analysis The identification of single nucleotide polymorphisms (SNPs) was performed using SAMtools mpileup ( GSH1 and GSH2 promoter regions, whereas putative binding sites for transcriptional factors near promoter sequences were identified with Yeastract ( GSH1 and GSH2 modelling to compare with those obtained from S. cerevisiae EC1118 (reference templates)