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We highlight developments in surgical and non-surgical therapies (mainly involving the combination of radiotherapy and chemotherapy), outlining how these treatments are being used in the current era of widespread testing for the presence of human papillomavirus infection in patients with HNSCC

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15 Botulinum toxin can be used in patients with focal TD 16,18 and alternative therapeutic modalities such as short-term treatment with vitamin B 6 , amantadine or deep brain stimulation can be considered if patients do not respond to more established therapies