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26 Exercise also induced brown adipose tissue-derived small EVs containing a group of miRNAs (miR-125b-5p, miR-128-3p, and miR-30d-5p), which protected against myocardial I/R injury through targeting the molecules (e.g., MAP3K5, MAP2K7, AND MAP2K4) involved in the pro-apoptotic MAPK signaling pathway

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This innovative feature reduces the risk to surrounding skin, ensuring a safe treatment process