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When compared to experimental and clinical data on the accumulation of the byproducts of acetaminophen metabolism, APAP-S, APAP-G, and NAPQI-GSH, in the plasma and in the urine of humans, the model gives accurate predictions (see Figures 2, 3, 4 and 5)

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5h) were gone in the eyes injected with AAV2-shTMEM19, In addition, erucamide-induced preservation of ONL and INL thicknesses was also lost in TMEM19-knockdown eyes (Extended Data Fig