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Polysaccharides fermented by LAB may also produce some functional oligosaccharides such as chitosan, algal, mannan, and galacto-oligosaccharides, which are beneficial to human intestinal health (Patel and Goyal, 2011) by modulating gut flora, promoting the production of short-chain fatty acids, strengthening the intestinal mucosal barrier, alleviating inflammation, and improving intestinal immunity (Cheng et al., 2019

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Recent studies suggest that intestinal I/R injury may alter this delicate equilibrium, facilitating the passage of peripheral inflammatory signals to the brain, leading to neuroinflammation, and eventually compromising cognitive performance (Song et al., 2020