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Langemeijer et al., 2009), suggesting that enhancing residual TET2 activity, or restoring the activity of functionally defective mutant TET2 proteins, could be a particularly viable therapeutic strategy for TET2 deficient hematological malignancies
Common Uses_Vitamin C
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4 Oxidative stress and antioxidants Oxidative stress, referring to an imbalance between ROS production and cellular/tissue antioxidant defence mechanisms, plays a pivotal role in the pathogenesis of numerous diseases, including T2DM and impaired bone healing ( 2 ·− ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (·OH), are generated as by-products of normal cellular metabolism and can be further produced by various enzymatic sources, including NADPH oxidases, xanthine oxidase, and the mitochondrial electron transport chain (97–102), and increased in T2DM patients due to hyperglycaemia and the accompanying elevations in oxidative stress (123)
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