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Reassess whether the medication still fits Once the biochemical terrain is improving, review whether the current drug is still helping, whether the dose is now excessive, whether a different medication class better matches the pattern, or whether side effects were being amplified by untreated nutrient problems

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2), as well as the Jumonjic (JmjC)-domain-containing histone demethylase and the m 6 A demethylase (FTO, AlkBs) are NHFe/α-KG-dependent dioxygenases (Shi, 2007