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It circulates in human plasma and cerebrospinal fluid naturally, co-localises with multiple pituitary hormones, and appears in peripheral tissues far from the CNS — yet no gene for it has been found through extensive genomic searches

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Regarding the role of oxidative stress in the pathophysiology of seizures, this research aims to explore how dimethyl itaconate may have a potential therapeutic avenue for protecting neuronal health during seizure events by measuring the activity of glutathione-dependent enzymes and behavioral performance in adult rats affected by seizures