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The vinyl carbamate lung carcinogenesis experiment has been extended more recently using the potent Nrf2 activator CDDO-Im and the weak Nrf2 activator dimethyl fumarate, and like CDDO-ethyl amide and CDDO-methyl ester, CDDO-Im was found to inhibit lung carcinogenesis but, unexpectedly, the weak Nrf2 activator dimethyl fumarate was found to increase lung carcinogenesis [398]