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Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5-oxoproline accumulation: an under diagnosed phenomenon | BMJ Case Reports

Further studies using whole-genome CRISPR-Cas9 knockout screening identified FDX1, LIAS, and DLAT, which are components of the lipoic acid (LA) pathway or the pyruvate dehydrogenase complex, as essential genes required for cuproptosis

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For every newly synthesized DNA or RNA base, an average of one 10-formyl-THF is required