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(2005) investigated the relationship of glutathione and AsA concentrations in the activation of plant innate stress responses through antioxidative metabolism and it was concluded that elevated levels of glutathione, its reduced form, and ascorbate deficiency triggers salicylic acid (SA) mediated signaling that is independent of H 2 O 2

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On the other hand, the key stress response adapter protein p62 competitively binds to Keap1 through its N-terminal Keap1-interacting region (KIR motif), forming a p62-Keap1 complex