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Preclinical studies utilizing FXN -silenced motor neurons and patient-derived cells have demonstrated that the FXN gene promoter contains highly conserved AREs, meaning Nrf2 directly drives FXN transcription in vitro [128,131,132]

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The succinylation of PGK1 disrupts the integrity of the blood-brain barrier by modulating the angiostatin/VEGF pathway, leading to alterations in seizure activity (183)

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