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Transient stress or increased cytoplasmic TDP-43 triggers phase separation into toxic cytoplasmic droplets that block nuclear import, deplete nuclear TDP-43, and cause cell death, offering a present mechanistic model for ALS/FTD pathology (Gasset-Rosa et al., 2019)

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Thus, investigating the efficacy of fingolimod and nicotinamide riboside for BIPN represents a promising direction for future clinical research