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Water-soluble vitamins, such as B12 and C, are more likely to lose their potency quickly

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In a randomized DBPC study of 141 children and adults with ASD, a MVI containing 500 mcg of oral cB12 led to significant improvements compared to placebo in total sulfate, SAM, reduced glutathione, GSSG:GSH, nitrotyrosine, adenosine triphosphate (ATP), NADH, and NADPH [49]