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When exposed to stimuli, Nrf2 detaches from the inhibitor protein Kelch-like ECH-associated protein 1 (Keap1) and translocates into the nucleus from the cytoplasm, where it binds to the antioxidant response element (ARE), leading to the upregulation of several antioxidant-related genes (e.g., HO-1 and NQO1) [230]

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W badaniach klinicznych wykazano, że regularne stosowanie preparatów o takim stężeniu przez okres od 4 do 12 tygodni prowadzi do widocznej poprawy kondycji skóry, w tym redukcji zmarszczek, poprawy elastyczności skóry i rozjaśnienia przebarwień