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This disulfide is reduced by thioredoxin, a small disulfide reductase, which was originally discovered as the reducer of ribonucleotide reductase, the enzyme that catalyzes the generation of deoxyribonucleotides from ribonucleotides and is necessary for DNA replication ( Figure 1B ) ( Figure 1 There are six mammalian peroxiredoxins of three different classes: typical 2-Cys, atypical 2-Cys, and 1-Cys

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