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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice - PMC

Further support for a direct contribution of glutamate in the disease process came from blocking studies, applying Memantine, an N-methyl-D-aspartate (NMDA) ionotropic glutamate receptor antagonist

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PMID: 34896831 Proc Natl Acad Sci U S A 2026 Apr 14;123(15):e2520128123