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This pattern underscores a targeted disruption in MYCN’s capacity to maintain proteostasis within the ER, which is further corroborated by the decreased presence of protein partners involved in misfolding management and chromatin structure regulation

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The cyclooxygenase enzyme was first identified as the therapeutic target of NSAIDs by Vane in 1971, showing that these anti-inflammatory substances block the biosynthesis of prostaglandins (PGs) that contribute to a variety of physiological and pathophysiological functions (2)