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3.1.4 Summary Collectively, metformin mitigates I/R injury through converging mechanisms including AMPK activation, mitochondrial preservation, suppression of inflammation and oxidative stress, and modulation of regulated cell death, which positions metformin as a multifaceted cardioprotective agent

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Absorption and distribution of tea catechin, (-)-epigallocatechin-3-gallate, in the rat