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Biochemistry of the GST enzymes The fundamental basis for all GST catalytic activities is the capacity of these enzymes to lower the pK a of the sulfhydryl group of reduced glutathione (GSH) from 9.0 in aqueous solution to about 6.5 when GSH is bound in the active site [12]

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Naturally found in onions and other Allium vegetables, NAC may be more readily absorbed and utilized by the body than supplemental glutathione itself.* Mechanism of Action Glutathione Precursor NAC is a key building block for glutathione synthesis, delivering the rate-limiting amino acid cysteine in a form that the body can readily use