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Thus, if iron restriction normally serves as a brake on erythropoiesis when iron availability is limited, aberrant inflammation-insensitive erythropoiesis in PV may hijack iron for hemoglobin synthesis at the expense of iron requirements for all other cell functions, depleting iron stores

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GlaxoSmithKline’s Ventolin HFA, 3M’s ProAir HFA, and others held patents covering not just the drug formulation but the specific valve and actuator designs used with the HFA propellant