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Whereas iBET-BD1 can block both dHTC3-induced ternary complex formation and BRD4 degradation, iBET-BD2 cannot do either (Fig

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Introduction In the realm of human health, sleep is pivotal, serving not only as a period for energy storage and nervous system recuperation but also as a critical phase for reinforcing brain connections, thereby augmenting learning and memory processes ( Addressing this challenge necessitates a paradigm shift in sleep regulation strategies, focusing on the development of therapeutic agents that prioritize safety and efficacy