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Research on COPD endotypes is advancing rapidly, and several specific endotypes have been proposed or identified, including the T2-low endotype (neutrophil-predominant), T2-high endotype (eosinophil-predominant), genetic endotypes (α1-antitrypsin deficiency endotype, telomerase gene mutation endotype), pulmonary vascular endotype, and persistent inflammation/autoimmune endotype (22)