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Symes, [email protected] Liaudanskaya, [email protected] †These authors share first authorship ‡These authors share senior authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Study of isolated aortic rings from diabetic rats showed that overexpression of GCH by gene transfer reverses diabetes-induced BH4 deficiency and restores NO bioavailability [159]