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Various alterations in the placentation process can have serious consequences during pregnancy and women presenting specific characteristics, including obesity, advanced maternal age, cardiovascular dysfunction, and metabolic syndrome, which are also related to endothelial damage, are at higher risk [7,8]

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As noted by Kraus et al., Nature Medicine , NNMT inhibition in white adipose tissue significantly increased energy expenditure and reduced fat mass in animal models without changes to diet or activity